Position
| Chromosome | chr21 |
| Start | 9544970 |
| End | 9576458 |
| Strand | + |
view in Gbrowse: chr21:9544970..9576458
Most similar sequence in NCBI nr database
| Accession | Description | E-value | Score |
|---|
| NP_001136084.1 | voltage-gated sodium channel alpha subunit | 0.0 | 4232 |
ORF sequence (6117 bp)
ATGTCCGAGGACTTGGACTCGATCAGCGAGGAAGAACGAAGCTTGTTCCGACCCTTCACACGAGAGTCTCTGGCCGCAATCGAAGCCCGCATAGCTGAAGAGCATGCCAAGCAAAAAGAACTCGAGAAAAAACGAGCGGAAGGCGAGGTGCGTTACGATGATGAGGATGAGGACGAGGGTCCCCAGCCGGACGCTACCTTGGAGCAAGGTCTACCACTGCCGGTGCGCATGCAAGGGTCCTTCCCGCTCGAACTCGCCTCTACACCACTCGAGGACATCGACCCCTTCTACCACAATCAGACAACCTTCGTAGTTATAAGCAAGGGTAAAGATATCTTCAGATTTTCGGCGACAAATGCTCTGTGGATATTAGACCCATTTAATCCCATAAGAAGAGTGGCTATATACATATTGGTACATCCTTTGTTTTCGCTGTTCATTATTACGACAATCTTAGTGAATTGCATACTTATGATAATGCCTACAACGCCAACAGTTGAAAGTACTGAAGTTATCTTTACCGGGATCTACACGTTTGAATCAGCGGTGAAAGTAATGGCCAGGGGTTTTATACTACAGCCATTCACATACCTTAGAGATGCATGGAATTGGCTTGACTTCGTAGTTATAGCTTTAGCTTATGTGACGATGGGCATAGATCTCGGAAACCTAGCCGCTCTGAGAACGTTCAGGGTACTACGAGCGTTGAAGACTGTGGCCATAGTACCGGGCTTGAAGACGATCGTCGGTGCTGTTATAGAATCCGTGAAAAATCTCCGTGATGTAATAATTTTAACGATGTTTTCGCTGTCCGTATTCGCGTTGATGGGCCTACAGATTTACATGGGAGTTTTGACGCAGAAGTGTGTCAAAGTGTTCCCGGAGGACGGCTCTTGGGGTAACCTGACCGACGAGAACTGGGAGAGGTTTTGTCAGAACGAAACTAACTGGTATGGTGAAGGGGGTGATTATCCTTTATGCGGCAATTCATCAGGGGCAGGACAATGCGAACCGGGCTACGTTTGTCTTCAAGGCTTCGGTCCAAATCCAAACTACGGATATACAAGCTTTGACACCTTCGGTTGGGCATTTCTATCAGCTTTCCGTCTAATGACACAGGATTATTGGGAAAATCTCTATCAATTGGTCTTAAGATCAGCTGGCTCGTGGCACGTATTGTTTTTCGTAGTGATAATATTCCTGGGATCTTTTTATCTGGTGAACTTGATTTTGGCTATCGTCGCCATGTCATACGATGAGCTACAGAAGAAAGCCGAAGAAGAAGAACAAGCAGAAGAAGAAGCTTTACGGGAGGCAGAGCAGAAAGCGGCAGCGAGAGCGGACAAACAAGAAGCACGAGAAGCCCACGCGAGAGAACAAGCGGCGGCCGCGGAGGCTGCAGCTTACGCCGAGGCGCATCCCGCCAAGTCGCCGAGTGACTTCTCCTGTCAAAGCTACGAGCTGTTCGTGAACCAGGAGCGGGGCAACCAAGACGACAATACCCGGGAACGCATGTCCCTACGTAGCGACCCCTTCCAGGACTCGGTGAGCACTCAGCCCGCGCACAAGCCCACCGCCACCGACACGCACGACTCCGCACGACGGCCGAGGAAGGTCAGCATGGCGTCTTTATCATTGCCTGGTTCTCCATTCAATTTGCGCCGTGGTTCACGTGGATCTCATCAGATGGCTCTGAGACCTAACGGTAGACCGAGATATCCTCCCGGAGGGGATCGGAAGCCACTGGTTTTGTCTACGTACCTCGATGCACAGGAACACCTGCCTTATGCTGATGACTCGAACGCTGTCACACCGATGTCTGAAGAAAATGGTGCTATCATCATCCCAGTTTATTATGCTAATTTAGGATCCCGACATTCTTCATACACGTCTCATCAGTCACGTTTGTCTTACACGTCTCACGGGGACTTGTTGGGCGGAGGGAAAGCTCAAACTAAGGAAGCTAGATTACGCGGCAGGTCCGCTTCTAGGAACCACAGTGTGACATCACAACCTCACGCCTATCCCTTACCTAGACAAGACTCCTCGCTAGCATCTAGACCCCTTAGAGAATATGAAGTAAGTACGACTGAGTGCACAGACGAAGCTGGAAAAGTTCTGAAACCATCAAGCGATAATCCGTTCATAGAATCGTCACAGCAGCCTAACGTAGTGGATATGAGAGACGTAATGGTATTAAATGAAATCATTGAACAGGCTGGACGTCAGAGTCGGGCGAGCGAACAAAACGTGTCAGTGTACTACTTCCCAACAGCCGAAGACGATGAAGATGGACCCACATTTAAGGAGAAACTACTCGATTGTCTAATGAAAGGAATAGACTTCTTCTGTGTGTGGGACTGTTGCTGGTTGTGGCTCGAGTTCCAAAAATACGTAGCGCTGTTGGTGTTCGATCCATTCGTCGAGTTGTTCATCACGCTCTGTATTGTTGTAAATACACTATTTATGGCTCTGGACCATCATAACATGGATAAAGACATGGACAAAGCGTTAAAAAGCGGCAATTATTTCTTCACGGCGACATTCGGCATAGAAGCAACACTAAAATTAATAGCAATGAGCCCGAAATATTATTTCCAAGAGGGATGGAATATTTTTGATTTCATTATTGTGGCCTTATCACTGCTTGAATTGGGGCTTGAGGGTGTTCAGGGTTTGTCGGTATTACGATCGTTTCGTTTGCTTCGAGTATTCAAATTGGCAAAGTCATGGCCGACTCTTAATTTACTCATCTCTATAATGGGTAGGACAATGGGTGCCTTGGGCAACCTGACCTTCGTATTGTGCATCATTATTTTCATATTTGCGGTGATGGGTATGCAACTGTTCGGAAAAAATTATGTCGATTACGTAGACCGGTTTCCTGATGGGGACCTTCCTCGGTGGAACTTCACGGATTTTATGCACAGTTTTATGATCGTATTCCGAGTGCTATGCGGAGAATGGATAGAAAGCATGTGGGATTGTATGTTGGTTGGAGATGTATCTTGCATACCATTTTTCTTGGCAACCGTCGTTATCGGAAACCTTGTGGTACTGAATCTCTTCTTAGCCCTGTTGCTCTCCAATTTTGGTTCCTCGAGCTTATCAACCCCAACAGCTGATCAAGACACGAACAAAATCGCGGAGGCTTTCAATAGAATATCGAGGTTCATTGACTGGATAAAACGGAACGTCGCAGACTTCCTCAAGCTACTGAAAAACAAACTCACCAATCAGATAGCTATACACGCGCCCGAGCGGGTCGACAACGAATTAGAACTAGGAACTGACCTCGATGACGCCGTACTCTATAAAGACAAGAAACTCAAAGATCAAGTCGAAGTGGCTATCGGAGATGGAATGGAATTCACAATACCAGGTGACAATAAATACAAAAAAGGTAAAATTTTGATGAATAACATAAATGCAATAACAGATAATCACAGGGACAATAGATTAGACTGTGAACTGAATCATCATGGATATCCTATTCAGGATGACGACACTATAAGTCAAAAATCTTACGGTAGTCACAAAATAAGATCATTCAAGGATGAAAGCCACAAAGGATCGGCCGATACGATAGATGGAGAAGAAAAGAAAGATGCAAGCAAAGAAGAACTTGGACTTGAAGAAGAATTGATTGAGGAAGACGAAGAGGGCAAACTTGATGGTACTTTAGGTAAAACGGATATAAAAGTAGGGGCCGATGAAGACGTTGTTGATGATACACCAGCCGATTGTTGTCCGGAGCAATGCTATCAAAAGTTTCCATTTCTTGCTGGAGACGACGACTCGCCTTTTTGGCAAGGCTGGGGCACTCTTCGGCTCAAAACGTTCAAACTCATTGAAAACACTTACTTTGAGACTGCAGTTATTACCATGATTTTACTGAGTAGTTTAGCATTGGCTTTAGAAGACGTACATTTACCACACCGTCCAATACTTCAAGACATTCTTTATTACATGGATCGTATCTTCACTGTTATATTCTTCATTGAGATGTTGATCAAGTGGCTTGCTCTCGGATTCCAAAAATATTTTACTAATGCTTGGTGCTGGCTTGATTTCATCATTGTGATGGTCTCGCTTATAAACTTCGTAGCGGCGCTTTGTGGTGCCGGAGGCATTCAGGCGTTCAAAACGATGAGAACACTGCGCGCACTGCGCCCGCTCAGAGCCATGAGCCGCATGCAGGGCATGAGGGTTGTTGTGAACGCCCTGGTACAGGCAATTCCATCCATCTTCAACGTACTCCTTGTATGTCTAATATTCTGGCTCATCTTCGCCATTATGGGTGTCCAGCTCTTTGCAGGAAAATACTTTAAGTGCGTTGATATGAATCACACCACTCTAAGCCACGAAATCATTCCGGATAAAAATGCATGCACCTTAGAAAACTATACATGGGAAAATTCACCAATGAACTTTGATCACGTGGGTAAAGCGTATTTATGTCTCTTCCAAGTGGCAACATTCAAAGGCTGGATCCAAATTATGAACGATGCAATTGACTCTAGGGAGGTGGGACGTCAGCCGATTCGAGAAACTAACATATACATGTACCTTTACTTTGTGTTCTTCATTATATTCGGTTCATTCTTCACTCTCAATCTGTTTATCGGAGTGATCATCGACAACTTCAACGAACAGAAAAAGAAAGCCGGGGGCAGTCTCGAAATGTTCATGACTGAAGATCAAAAGAAATACTATAACGCCATGAAGAAAATGGGTTCTAAAAAGCCTTTGAAAGCGATTCCAAGACCAAGGTGGCGACCACAAGCAATCGTGTTCGAGATAGTCACTGACAAGAAGTTTGACATGATTATCATGTTGTTCATTGGATTAAACATGCTCACGATGACATTGGACCACTACCAACAGTCGGAAACGTTTAGCGCCGTCCTCGACTATCTCAATATGATATTCATAGTGATATTTAGTTCAGAGTGCCTATTGAAAATATTCGCCTTACGTTATCACTATTTTGTTGAACCATGGAATCTTTTCGATTTCGTCGTAGTTATGTTTTCTATTCTTAGCTTGGTGCTCAGTGACATTATAGAAAAATATTTTGTATCTCCTACGCTACTAAGAGTGGTGCGAGTAGCAAAAGTTGGTCGAGTCCTTCGACTCGTGAAAGGCGCTAAAGGGATACGAACGTTGTTGTTCGCTTTGGCTATGTCGCTGCCGGCTTTGTTCAATATTTGCCTACTCTTGTTCCTGGTCATGTTTATTTTTGCCATATTCGGCATGTCATTCTTCATGCACGTTAAAGACAAAGGTGGTCTGGACGACGTGTATAACTTCAAAACATTCGTGCAGAGTATGATTTTACTGTTCCAGATGTCAACGTCTGCCGGTTGGGATGGAGTTTTAGATGGTATTATAAATGAGGAAGAATGTGATCTTCCCGACAACGAACGAGGATCGCCAGGAAACTGTGGCTCTGCAACCATAGGCATAACTTACCTACTATCATACCTTGTCATTTCTTTTCTCATCGTCATCAACATGTACATCGCCGTCATTCTCGAGAATTACTCTCAGGCAACAGAAGACGTGCAGGAAGGATTGACAGATGACGACTACGACATGTACTACGAAATCTGGCAGCGGTTCGACCCGGACGGTAGTCAGTACATTAGATACGATCAGCTCTCAGATTTCCTTGACGTCTTGGAACCGCCATTACAAATCCACAAACCTAACAAATACAAAATTATATCGATGGACATACCGATATGTCGCGGCGACATGATGTTCTGCGTCGACATTCTCGACGCACTGACGAAAGATTTCTTCGCTCGAAAAGGGAATCCCATTGAGGAGACGGGTGATTTGGAAGTGGGTCGTCCTGAAGAAGCGGGCTACGAGCCAGTGTCGTCGACGCTGTGGCGGCAGCGCGAGGAGTACTGTGCGCGACTGATACAGCACGCGTGGCGACGGCATCGGCGTGCACACGAGGAGCCCGAAGTGGGCGGCGGAGCGGAGGGTGCAGCCACGGCCGTGTTGCTGGACGCCGTGACTCCTAACGGTCACCGCGTGGTTCTGCAGGGTGGCGGCGCAGCCCCCCGACCCCCGGAGCCCGCGCCACCACCCGCGTCCGTCTGA
Protein sequence (2038 aa)
MSEDLDSISEEERSLFRPFTRESLAAIEARIAEEHAKQKELEKKRAEGEVRYDDEDEDEGPQPDATLEQGLPLPVRMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQLVLRSAGSWHVLFFVVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEQAEEEALREAEQKAAARADKQEAREAHAREQAAAAEAAAYAEAHPAKSPSDFSCQSYELFVNQERGNQDDNTRERMSLRSDPFQDSVSTQPAHKPTATDTHDSARRPRKVSMASLSLPGSPFNLRRGSRGSHQMALRPNGRPRYPPGGDRKPLVLSTYLDAQEHLPYADDSNAVTPMSEENGAIIIPVYYANLGSRHSSYTSHQSRLSYTSHGDLLGGGKAQTKEARLRGRSASRNHSVTSQPHAYPLPRQDSSLASRPLREYEVSTTECTDEAGKVLKPSSDNPFIESSQQPNVVDMRDVMVLNEIIEQAGRQSRASEQNVSVYYFPTAEDDEDGPTFKEKLLDCLMKGIDFFCVWDCCWLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYFFTATFGIEATLKLIAMSPKYYFQEGWNIFDFIIVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMLVGDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSTPTADQDTNKIAEAFNRISRFIDWIKRNVADFLKLLKNKLTNQIAIHAPERVDNELELGTDLDDAVLYKDKKLKDQVEVAIGDGMEFTIPGDNKYKKGKILMNNINAITDNHRDNRLDCELNHHGYPIQDDDTISQKSYGSHKIRSFKDESHKGSADTIDGEEKKDASKEELGLEEELIEEDEEGKLDGTLGKTDIKVGADEDVVDDTPADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKGNPIEETGDLEVGRPEEAGYEPVSSTLWRQREEYCARLIQHAWRRHRRAHEEPEVGGGAEGAATAVLLDAVTPNGHRVVLQGGGAAPRPPEPAPPPASV
Domains and motifs
| Database | ID | Description | Start | End | Evalue | InterPro ID |
|---|
| PANTHER | PTHR10037 | - |
127 | 220 | 0.0 |
- |
| PANTHER | PTHR10037:SF288 | - |
127 | 220 | 0.0 |
- |
| Gene3D | 1.20.120.350 | - |
134 | 243 | 7.6e-21 |
IPR027359 |
| Pfam | PF00520 | Ion transport protein |
140 | 425 | 4.6e-71 |
IPR005821 |
| SUPERFAMILY | SSF81324 | - |
140 | 418 | 2.4e-28 |
- |
| PANTHER | PTHR10037 | - |
213 | 1991 | 0.0 |
- |
| PANTHER | PTHR10037:SF288 | - |
213 | 1991 | 0.0 |
- |
| Gene3D | 1.10.287.70 | - |
340 | 415 | 4.5e-12 |
- |
| Pfam | PF11933 | Cytoplasmic domain of voltage-gated Na+ ion channel |
502 | 729 | 2.6e-37 |
IPR024583 |
| Gene3D | 1.20.120.350 | - |
796 | 910 | 1.9e-32 |
IPR027359 |
| Pfam | PF00520 | Ion transport protein |
806 | 1033 | 1.2e-51 |
IPR005821 |
| SUPERFAMILY | SSF81324 | - |
806 | 1031 | 5.3e-29 |
- |
| Gene3D | 1.10.287.70 | - |
912 | 1035 | 1.3e-18 |
- |
| Pfam | PF06512 | Sodium ion transport-associated |
1042 | 1282 | 5.0e-34 |
IPR010526 |
| Gene3D | 1.20.120.350 | - |
1278 | 1398 | 2.8e-28 |
IPR027359 |
| Pfam | PF00520 | Ion transport protein |
1287 | 1556 | 8.1e-66 |
IPR005821 |
| SUPERFAMILY | SSF81324 | - |
1287 | 1553 | 1.9e-40 |
- |
| CDD | cd13433 | Na_channel_gate |
1547 | 1599 | 4.3e-29 |
- |
| Gene3D | 1.20.120.350 | - |
1596 | 1717 | 2.7e-39 |
IPR027359 |
| SUPERFAMILY | SSF81324 | - |
1606 | 1851 | 5.3e-32 |
- |
| Pfam | PF00520 | Ion transport protein |
1607 | 1856 | 1.1e-55 |
IPR005821 |
| Gene3D | 1.10.287.70 | - |
1719 | 1850 | 1.3e-20 |
- |
| Gene3D | 1.10.238.10 | - |
1851 | 1965 | 4.4e-35 |
- |
| ProSiteProfiles | PS50222 | EF-hand calcium-binding domain profile. |
1863 | 1898 | 9.994 |
IPR002048 |
InterPro assignment
| InterPro ID | InterPro description |
|---|
| IPR002048 | EF-hand domain |
| IPR005821 | Ion transport domain |
| IPR010526 | Sodium ion transport-associated |
| IPR024583 | Voltage-gated Na+ ion channel, cytoplasmic domain |
| IPR027359 | Voltage-dependent channel domain superfamily |
Gene ontology (GO) assignment
| GO category | GO ID | GO description |
|---|
| cellular component | GO:0001518 | voltage-gated sodium channel complex |
| molecular function | GO:0005216 | ion channel activity |
| molecular function | GO:0005248 | voltage-gated sodium channel activity |
| molecular function | GO:0005509 | calcium ion binding |
| biological process | GO:0006811 | ion transport |
| biological process | GO:0006814 | sodium ion transport |
| cellular component | GO:0016020 | membrane |
| biological process | GO:0055085 | transmembrane transport |