Position
| Chromosome | chr5 |
| Start | 10088405 |
| End | 10091974 |
| Strand | - |
view in Gbrowse: chr5:10088405..10091974
Most similar sequence in NCBI nr database
| Accession | Description | E-value | Score |
|---|
| NP_001166819.1 | nicotinic acetylcholine receptor subunit beta 1 isoform 1 precursor | 0.0 | 1099 |
ORF sequence (1602 bp)
ATGTACCCGCATCCGGCAGTGCCCGCTGCAATGTCGTGCGTATCGCGCGCTTTCCTCGCCACCACCCTACTGGCCATCCTGTATTCAGGATGGTGTTCAGAAGACGAAGAACGTTTAGTTCGCGACCTTTTCAGAGGATACAATAAATTAATACGACCTGTCCAAAACATGACACAGAAAGTGGATGTGAGATTTGGTCTTGCGTTTGTACAACTCATTAACGTCAATGAGAAGAACCAAATTATGAAATCAAACGTTTGGCTCCGTTTGGTTTGGATGGATTACCAGTTGATGTGGGACGAAGCTGACTACGGCGGTATTGGCGTATTAAGATTACCGCCTGACAAGGTTTGGAAGCCAGATATAGTTCTTTTCAATAACGCTGACGGAAATTACGAAGTCCGATATAAATCAAACGTGCTTATATATCCTAATGGAGAAGTACTTTGGGTCCCACCAGCTATATATCAGAGCTCGTGCACGATTGACGTAACCTACTTTCCATTTGACCAGCAAACGTGTATCATGAAATTCGGATCTTGGACGTTCAATGGGGACCAAGTATCACTGGCGCTATACAACAACAAGAACTTTGTTGATCTTTCCGATTATTGGAAGTCAGGAACATGGGATATCATAGAAGTACCGGCTTATTTGAACATTTATGAAGGCAATCATCCAACTGAAACTGATATTACGTTCTACATTATAATTCGACGGAAAACATTGTTTTACACTGTAAACTTAATATTGCCGACTGTTTTAATTTCGTTTCTTTGTGTACTTGTATTTTATTTGCCAGCTGAAGCTGGTGAAAAGGTAACCTTGGGTATCAGCATTTTACTTTCTCTGGTTGTGTTCCTGCTTCTGGTATCGAAGATTCTTCCACCGACATCGCTTGTACTTCCACTTATCGCTAAATATTTATTATTCACATTCATTATGAATACTGTCAGTATTCTGGTTACGGTTATCATAATCAATTGGAACTTCAGAGGACCCAGAACTCATAGGATGCCATTATGGATTCGAAGCGTTTTCCTGCATTATTTACCAGCTATGCTGCTTATGCGGAGACCGAGAAAAACTAGATTGCGCTGGATGATGGAAATGCCCGGAATGGGTGCTCCACCCCATGCAGCGGCACCACACGACCTCCCGAAACATATAAGTGCGATTGGTACCAAACAAAGCAAAATGGAGGCAATGGAGCTATCGGACCTACATCATCCAAATTGCAAAATAAACCGTGCTGCCGGCGGAGGTGAAGTTGGCGCTCTTGGAGATCTTGGTGCACTGGGTGGTCTGGGACTTGGAGGAGAAAGACGCGAATCGGAAAGTTCGGATTCACTTCTACTTTCTCCTGAAGCGGCAAAGGCTACGGAAGCAGTCGAATTCATTGCGGAACATTTACGAAATGAAGATCTTTACATTCAGACTCGCGAAGACTGGAAATACGTGGCAATGGTTATTGACAGATTACAGCTGTACATTTTCTTCATAGTCACCACAGCAGGAACGGTTGGGATACTGATGGATGCACCACATATTTTCGAATATGTTGACCAAGATCGTATTATTGAAATTTATCGAGGAAAATAA
Protein sequence (533 aa)
MYPHPAVPAAMSCVSRAFLATTLLAILYSGWCSEDEERLVRDLFRGYNKLIRPVQNMTQKVDVRFGLAFVQLINVNEKNQIMKSNVWLRLVWMDYQLMWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPNGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTWDIIEVPAYLNIYEGNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPLWIRSVFLHYLPAMLLMRRPRKTRLRWMMEMPGMGAPPHAAAPHDLPKHISAIGTKQSKMEAMELSDLHHPNCKINRAAGGGEVGALGDLGALGGLGLGGERRESESSDSLLLSPEAAKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDAPHIFEYVDQDRIIEIYRGK
Domains and motifs
| Database | ID | Description | Start | End | Evalue | InterPro ID |
|---|
| TIGRFAM | TIGR00860 | LIC: cation transporter family protein |
32 | 512 | 2.4e-98 |
IPR006201 |
| CDD | cd19032 | LGIC_ECD_nAChR_proto_beta-like |
35 | 242 | 6.0e-152 |
- |
| PANTHER | PTHR18945 | - |
35 | 522 | 6.8e-205 |
IPR006201 |
| PANTHER | PTHR18945:SF784 | - |
35 | 522 | 6.8e-205 |
- |
| SUPERFAMILY | SSF63712 | - |
35 | 241 | 2.9e-67 |
IPR036734 |
| Gene3D | 2.70.170.10 | - |
36 | 245 | 6.1e-80 |
IPR036734 |
| Pfam | PF02931 | Neurotransmitter-gated ion-channel ligand binding domain |
36 | 242 | 4.1e-73 |
IPR006202 |
| ProSitePatterns | PS00236 | Neurotransmitter-gated ion-channels signature. |
160 | 174 | - |
IPR018000 |
| SUPERFAMILY | SSF90112 | - |
242 | 518 | 1.1e-76 |
IPR036719 |
| CDD | cd19064 | LGIC_TM_nAChR |
243 | 332 | 1.3e-39 |
- |
| Gene3D | 1.20.58.390 | - |
246 | 360 | 1.6e-42 |
- |
| Pfam | PF02932 | Neurotransmitter-gated ion-channel transmembrane region |
249 | 511 | 6.6e-73 |
IPR006029 |
| Gene3D | 1.20.58.390 | - |
451 | 523 | 5.1e-16 |
- |
InterPro assignment
| InterPro ID | InterPro description |
|---|
| IPR006029 | Neurotransmitter-gated ion-channel transmembrane domain |
| IPR006201 | Neurotransmitter-gated ion-channel |
| IPR006202 | Neurotransmitter-gated ion-channel ligand-binding domain |
| IPR018000 | Neurotransmitter-gated ion-channel, conserved site |
| IPR036719 | Neurotransmitter-gated ion-channel transmembrane domain superfamily |
| IPR036734 | Neurotransmitter-gated ion-channel ligand-binding domain superfamily |
Gene ontology (GO) assignment
| GO category | GO ID | GO description |
|---|
| molecular function | GO:0004888 | transmembrane signaling receptor activity |
| molecular function | GO:0005216 | ion channel activity |
| molecular function | GO:0005230 | extracellular ligand-gated ion channel activity |
| biological process | GO:0006811 | ion transport |
| cellular component | GO:0016021 | integral component of membrane |
| biological process | GO:0034220 | ion transmembrane transport |