Position
| Chromosome | chr12 |
| Start | 10041199 |
| End | 10058913 |
| Strand | - |
view in Gbrowse: chr12:10041199..10058913
Most similar sequence in NCBI nr database
| Accession | Description | E-value | Score |
|---|
| XP_028032428.1 | multidrug resistance-associated protein 7 | 0.0 | 3273 |
ORF sequence (4785 bp)
ATGTCTTTTATATTGAATATAAATTGGAAATGGGAAGATATGTGCGGGCCTGGAGGGCTTCATCCATGGAATGATGCCACGAAAGACTTCAGCGTGTGTTTTCAAGAGCTATTCTTACAAGTACCAGTGTACTTTATAATAGCTATAGTATCAGGGTATTTTGTTGGATATCGAAAAGATTGGGTGATACGAGAAAAAACTCAAGAACGTGCCATAATATTTCGAAGTTTTGTTGTTTTAGGCTTAGCCTTCATACCGATCATAGAAATATATATATTTACTACCAAACCTGACTTCACTCTATATCCAGTAGACTATTTTGCTGCTGGTTCATCCTGTTTAGCATGGCTGGTGCACTTTGGATATGTTTTAGCATTGAAACACCGTCTTGGGCGTAGCTCTCGAGGTCCAGTAATGCAATTATTTTTATGGTGCTGTACAGTTCTTTTAAACCTGATAGCTCTCCGTAGCAACATCATTTCTGGTTCACAAACAGGTTTCAATACAGCTGCATTATGTTGTCACGTACTGTATTTTTTAACTCTGATTCCTTCAAATTACTCACGACCAACATTTTACTCGCCATGCTTAGTAGGCTCCCAACACTCTCATAGCGAGTACACTCCACTGATACCCCATGTAGATGATGATGTTCTTGGTACAGCTATGCAGGGCAACAGCTTTTTTTCAAAGTTGATGTTTACTTGGGTGAACCCTTTGCTACAAAAAGGTCTGGAGAATAAACTAAAAGATCCTGAAGAACTTTTCGACATACCAGCAGAATATCGTAGTTCATATATTGGTGCCAGAATGGATCGAGCATTGGTTGGAAATGTTGATCATCACCAACAATATGCTGATATACCACATGAACCTTTTATAAGCACAGGATATGGAGCTATAGGTGAAACAGTGCCACAAGCCTCAACACCTGTAACATCAACATCACGAGTTCGGGTCCACCCCGTACGACGACAAAATGTTTCCTTATTACGAGCACTGCATAAGGTTTTTGCAGTAGAGTTTTACAGTATTGGTTTACTTAAATTGGTATCTGATATGGCAGGTTTTGCAGGACCTCTTTTATTGAATAAGTTGGTTGAATTTGTTGAAGATACTACAATTGATGAACATATTGGGTATACTTTTGCAGTTAGTCTTTTGATAGCAACATTAGGATCGACCATATTTATTGTCCAATTTAATTGGTTAATGTCCATAATTGGACTAAAGATGCGTGGTGCGCTAGTCACCACCATTCTAAGGAAAACCTTAAGTGTGACTTCAACTGAGCTGACTAAAGCGTTCTCTGTTGGTGAAATAACAAATTTTATGTCTACTGATACTGATAGGATTGTGAATTCATGTCCTAGTTTTCATGCTCTATGGAGTATACCATTACAGTTATTTATAACACTGTTTTTATTGTATCAACAAGTGGGACTATCTTTCCTTGCTGGAGTAGGCTTTTCAGTTATTCTAATACCAATAAACAAACTTATTGCAAATAAAATTGGGCAATTAAGCACAGAGTTGATGAAGCATAAGGACACTAGAGTCAGTTTGATCAGTGATTTGCTAAAAGGAATTAGAACTGTAAAGGTTCATGTTTGGGAAGATTATTTTGTGGACAGAGTATCAGGGGCACGTGCAGAAGAGATGCGTTACCTCCGAGGCCGCAAGTATTTGGACGCGGTATGTGTTGTATTGTGGGCTACAACACCGGTGCTGGTCGCAGCACTGACGCTTGGTACACATGCGCTGCGGGGACAACCCCTAGAAGCACCGACTGTATTTACAACAGTTGCCTTAATAAATATGTTGATAGCTCCATTGAATGCGTTTCCTTGGGTCCTGAACGGCCTCACAGAGGCTTGGGTTTCAATAAAACGAATACAGAAGCTTTTGGATTTACCGGACATGAATTCGGAGGAGTACTACGACCGTGTCAACGTGAACAGAGATGAAGATAAAATAATAATATTCAGAAACGCTACTTTTGCGTGGGCCAGACCTATGAAACGAGATAATATGAAGTTAAATAAAGAAAAGGGGAAGTCGAATAAGAATAAACGAAAGCTTAATATTCAGAGGAGTGATTCTCTCACGTCCGAAGAAGGCGGACAAGATGCGCCCTTTACATTGAAGGATATATCATTAGAAATTGGAAGAGAAGAATTTATAGGTGTGACCGGATCTATTGGTAGCGGAAAAACATCTTTACTGCTGGCTGTTATTGGTGAAATGTTAAAGAAAAATGGAGATCTTCAACTTCCAGAAAGTCTCAACAGCTTTGGATACGTAGCACAAAAGCCATGGTTAATACGTGGGACTATTCGTGATAATATTTTGTTCGGGAAACCTTATGACGAAACAAAATTTAAATCGGTGATCGACGCATGTGCTTTAACAGAAGATTTAAATGTACTCGGTTGGAACGCGTATGTCGGTGAAGGTGGATGTACGCTAAGCGGAGGACAGCGTGCTAGAATCGCTTTGGCACGAGCTGTATATCAAGATAAACAAGTATACTTATTGGACGATGTGTTGGCGGGTCTGGATGCCCGTGTGTCGCAGCACGTGTTACAACACTGCCTGATGGGCTTGTTGCGACACACGACGCGACTGTTCGTCGCACAATCACCGAAACATCTAGCTAGAGTCTCACGTCTACTGGTACTGCGTGAAGGCCGTATAGTTAACGAAGGACCCCCTGAAATGATCTTACACGATATTGAGGAATATTTGCCAAGTGATTCAGAATCTTTGGGAGACGATCTTCCTAGGCAAAAACAGATTGAACAATCTGATGAAGATAACATCAGCAGAAATAGCTTGGATGATGAAGAAACAGTGTCAGAAGGAACCGTCGGTTTTTGGGTCATTGGATTATATTTGAAATCAGTTGGAATATTTCTCACTGTCGCAATAACGCTATCTCTAATACTAATGCAAGTCTCGCAGAATTTCACATTCTTTTGGCTAACGATATGGTTGAAGAACAGAACTAAGAATTCTACAGCTCTGACCGACTCTGAGTTCAATTTTCACGAGAACACGACTGTTCTAGACCATAGCTTTAACGCTGTAGACGGCATCGTTCATAAACTCATCAACACGACAATGATGTTGATAAATTCTATTGACGGGCATAAAAACAATGTCAGCGAGCCATCATTAAGCTCGACCCTCACTAATGCCCGTGCGACACTAGAAATCAGTATACCACAGTACAACGACAACTTCTACTTGGAAGCGTACTTCGGATTGGCTGGATTAAATCTTGTGTTCACTGTAATGAGGGCTTTCCTCTTCGCTTATGGAGGCGTGAAAGCAGCTACTAAAATACACAAAGTGCTTTTGAAAGTTATTGTCAGGGCACAAGTGAAATTTTTTGACGTCACTCCTATTGGAAGAATTGTTAATCGTTTTTCATCTGACACGTATACAGTTGACGATTCGTTACCTTTTATTTTGAATATACTTTTGGCTCAATTCTTTTCTCTCATTGGCGCACTGGCGGTGACAATATACGGGTTGCCGTGGCTGCTGGTGGGCGTGGCGCCCCTCGCCTTCGTGTACTACCGGCTGCAGCGCGTCTACCGCATCACCTCGCGACAACTGAAACGTCTACAGAGCGTCACTCTCTCCCCTATCTACACGCACTTCAACGACACCCTCGAAGGTTTGAGTAGCATACGCGCGCTGGGCGGCGCGGCGGCGTGGGAGGAGCGCGGCTGCGAACTCGTGGAGTCGTGGCAGCGTGCGGCGCTCAGCGCGAGCGGCGCGGCGCAGTGGCTGGCGCTGCGACTGCAGGCCGCCGCCGCCGTTCTCGTGGTAGCGGCCGCCGCGCTGGCTGTGCTGCAGAGGACGCTGCACACCGCCGACCCAGGGTTGGTGGGTCTGGCGATATCCTACGCGCTATCCATGACTTCGATGTTGAGCAATGTGCTCAATTCTTTTACGGAAACCGAACGAGAAATGATAGCCGTCGAAAGGGTAGGAGAATATATTAGACAGGTTGAAATTGAGAGTGTCGACGGTGAATCTCCTCCATACGGTTGGCCGTCACATGGCGTTGTTGAGTTTGATGATGTCCACCTTAACTACAGTGTCCGCGAGAGGGCGACGGCTGCGTTGTGCGGCGTGTCGTTCACGAGCTGGGCCGGCGAGAAGCTCGGCGTCGTGGGACGCACTGGCGCCGGGAAGAGCTCGCTGCTCGCCGCGCTGCTCCGGCTGGCGCCGCTCTCGCGGGGGACAGTGCGAGTCGACGGCGTCGACGTACACAAGCTACATCTGCATTCACTCAGGTCTCGTATCGGAGTGATACCGCAGGAGCCGTTCATATTCAGCGGCTCGATCCGCGAGAACGTGGACCCGCTCCGTCAGTACTCGGAGACGGAGGTGTGGCGCGCGCTGGAGGCGTGCGGGGTGAGGGACGCGGTGTCGGCCCGCGGCGGCCTGCACCACTCCGCCGCCTCGCTGTCCCGCGGCCACGCGCAGCTGCTGTGTCTCACGCGAGCGCTGCTGCAGCGCGCCAAGGTTCTTTTGGTTGACGAAGCCACCGCGAACCTCGACCAAGATACCGAGCGATTGATCCTTGATACGATTCGGTGTTCGTTCAGCGGCGCGACGGTCCTGTTCGTGGCGCACCGACTGGCCGGCGTGCTGGAGTGCTCGCGCGTGCTCGTGCTCGGCGGGGGGAAGGTTCTGGAACTGCGCACGCCCGACGACGCGCTTTCCGATCAAACCTCTTACTTTTACAACATGCTCTACGCTTCATAG
Protein sequence (1594 aa)
MSFILNINWKWEDMCGPGGLHPWNDATKDFSVCFQELFLQVPVYFIIAIVSGYFVGYRKDWVIREKTQERAIIFRSFVVLGLAFIPIIEIYIFTTKPDFTLYPVDYFAAGSSCLAWLVHFGYVLALKHRLGRSSRGPVMQLFLWCCTVLLNLIALRSNIISGSQTGFNTAALCCHVLYFLTLIPSNYSRPTFYSPCLVGSQHSHSEYTPLIPHVDDDVLGTAMQGNSFFSKLMFTWVNPLLQKGLENKLKDPEELFDIPAEYRSSYIGARMDRALVGNVDHHQQYADIPHEPFISTGYGAIGETVPQASTPVTSTSRVRVHPVRRQNVSLLRALHKVFAVEFYSIGLLKLVSDMAGFAGPLLLNKLVEFVEDTTIDEHIGYTFAVSLLIATLGSTIFIVQFNWLMSIIGLKMRGALVTTILRKTLSVTSTELTKAFSVGEITNFMSTDTDRIVNSCPSFHALWSIPLQLFITLFLLYQQVGLSFLAGVGFSVILIPINKLIANKIGQLSTELMKHKDTRVSLISDLLKGIRTVKVHVWEDYFVDRVSGARAEEMRYLRGRKYLDAVCVVLWATTPVLVAALTLGTHALRGQPLEAPTVFTTVALINMLIAPLNAFPWVLNGLTEAWVSIKRIQKLLDLPDMNSEEYYDRVNVNRDEDKIIIFRNATFAWARPMKRDNMKLNKEKGKSNKNKRKLNIQRSDSLTSEEGGQDAPFTLKDISLEIGREEFIGVTGSIGSGKTSLLLAVIGEMLKKNGDLQLPESLNSFGYVAQKPWLIRGTIRDNILFGKPYDETKFKSVIDACALTEDLNVLGWNAYVGEGGCTLSGGQRARIALARAVYQDKQVYLLDDVLAGLDARVSQHVLQHCLMGLLRHTTRLFVAQSPKHLARVSRLLVLREGRIVNEGPPEMILHDIEEYLPSDSESLGDDLPRQKQIEQSDEDNISRNSLDDEETVSEGTVGFWVIGLYLKSVGIFLTVAITLSLILMQVSQNFTFFWLTIWLKNRTKNSTALTDSEFNFHENTTVLDHSFNAVDGIVHKLINTTMMLINSIDGHKNNVSEPSLSSTLTNARATLEISIPQYNDNFYLEAYFGLAGLNLVFTVMRAFLFAYGGVKAATKIHKVLLKVIVRAQVKFFDVTPIGRIVNRFSSDTYTVDDSLPFILNILLAQFFSLIGALAVTIYGLPWLLVGVAPLAFVYYRLQRVYRITSRQLKRLQSVTLSPIYTHFNDTLEGLSSIRALGGAAAWEERGCELVESWQRAALSASGAAQWLALRLQAAAAVLVVAAAALAVLQRTLHTADPGLVGLAISYALSMTSMLSNVLNSFTETEREMIAVERVGEYIRQVEIESVDGESPPYGWPSHGVVEFDDVHLNYSVRERATAALCGVSFTSWAGEKLGVVGRTGAGKSSLLAALLRLAPLSRGTVRVDGVDVHKLHLHSLRSRIGVIPQEPFIFSGSIRENVDPLRQYSETEVWRALEACGVRDAVSARGGLHHSAASLSRGHAQLLCLTRALLQRAKVLLVDEATANLDQDTERLILDTIRCSFSGATVLFVAHRLAGVLECSRVLVLGGGKVLELRTPDDALSDQTSYFYNMLYAS
Domains and motifs
| Database | ID | Description | Start | End | Evalue | InterPro ID |
|---|
| PANTHER | PTHR24223 | - |
234 | 1570 | 0.0 |
- |
| PANTHER | PTHR24223:SF330 | - |
234 | 1570 | 0.0 |
- |
| Gene3D | 1.20.1560.10 | - |
331 | 639 | 2.5e-23 |
IPR036640 |
| SUPERFAMILY | SSF90123 | - |
333 | 640 | 1.1e-34 |
IPR036640 |
| CDD | cd18598 | ABC_6TM_MRP7_D1_like |
344 | 632 | 7.8e-139 |
- |
| Pfam | PF00664 | ABC transporter transmembrane region |
345 | 612 | 2.7e-30 |
IPR011527 |
| ProSiteProfiles | PS50929 | ABC transporter integral membrane type-1 fused domain profile. |
345 | 624 | 32.402 |
IPR011527 |
| Gene3D | 3.40.50.300 | - |
666 | 942 | 5.1e-59 |
- |
| ProSiteProfiles | PS50893 | ATP-binding cassette, ABC transporter-type domain profile. |
696 | 921 | 18.968 |
IPR003439 |
| CDD | cd03250 | ABCC_MRP_domain1 |
698 | 898 | 2.5e-80 |
- |
| SUPERFAMILY | SSF52540 | - |
710 | 911 | 3.2e-43 |
IPR027417 |
| Pfam | PF00005 | ABC transporter |
715 | 849 | 1.7e-17 |
IPR003439 |
| SMART | SM00382 | - |
724 | 906 | 3.4e-06 |
IPR003593 |
| ProSitePatterns | PS00211 | ABC transporters family signature. |
823 | 837 | - |
IPR017871 |
| CDD | cd18605 | ABC_6TM_MRP7_D2_like |
974 | 1338 | 1.8e-112 |
- |
| Gene3D | 1.20.1560.10 | - |
1060 | 1344 | 2.3e-34 |
IPR036640 |
| Pfam | PF00664 | ABC transporter transmembrane region |
1074 | 1308 | 1.9e-34 |
IPR011527 |
| SUPERFAMILY | SSF90123 | - |
1075 | 1344 | 6.0e-46 |
IPR036640 |
| ProSiteProfiles | PS50929 | ABC transporter integral membrane type-1 fused domain profile. |
1086 | 1326 | 33.746 |
IPR011527 |
| Gene3D | 3.40.50.300 | - |
1345 | 1594 | 9.8e-71 |
- |
| SUPERFAMILY | SSF52540 | - |
1351 | 1587 | 1.3e-55 |
IPR027417 |
| ProSiteProfiles | PS50893 | ATP-binding cassette, ABC transporter-type domain profile. |
1361 | 1592 | 17.514 |
IPR003439 |
| Pfam | PF00005 | ABC transporter |
1382 | 1523 | 8.5e-28 |
IPR003439 |
| SMART | SM00382 | - |
1389 | 1577 | 8.4e-12 |
IPR003593 |
InterPro assignment
| InterPro ID | InterPro description |
|---|
| IPR003439 | ABC transporter-like |
| IPR003593 | AAA+ ATPase domain |
| IPR011527 | ABC transporter type 1, transmembrane domain |
| IPR017871 | ABC transporter, conserved site |
| IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| IPR036640 | ABC transporter type 1, transmembrane domain superfamily |
Gene ontology (GO) assignment
| GO category | GO ID | GO description |
|---|
| molecular function | GO:0005524 | ATP binding |
| cellular component | GO:0016021 | integral component of membrane |
| molecular function | GO:0016887 | ATPase activity |
| molecular function | GO:0042626 | ATPase-coupled transmembrane transporter activity |
| biological process | GO:0055085 | transmembrane transport |